Identification and determination of acrylamide by UPLC-MS / MS

Acrylamide [79-06-1] is a synthetic compound used in particular as a monomer for the manufacture of polyacrylamides (PAM). These high molecular weight polymers (C3H5ON) find numerous applications in industry: adjuvant, binder, flocculating agent, fixing agent, waterproofing agent, sealing agent, etc.


Polyacrylamides have found multiple applications, in particular thanks to their ability to retain up to 400 times their volume in water. They are therefore widely found in cosmetic products as a moisturizing base, hand creams and foundations or even in paramedical products such as skincare creams, make-up removers or even products formulated in the form of capsules. Also used for its flocculant properties in sanitary napkins or baby diapers, these polymers are very present in our daily life.

Control of residual monomer therefore becomes a necessity since Acrylamide is classified as a neurotoxic molecule as probably carcinogenic by the IARC (International Agency for Research on Cancer), it is therefore important to monitor its residual content.

Identification et dosage de l’acrylamide

Acrylamide is also a compound appearing during the cooking of compounds, especially plants, above 120 ° C.
From the early 2000s, the high-temperature cooking of certain foods, in particular foods of plant origin rich in carbohydrates such as fries, crisps, coffee, pastries, bread and cereals, was called into question. results in the formation of Acrylamide in relatively large and unexpected amounts.


The Polymex laboratory therefore suggests that you measure Acrylamide [79-06-1] by UPLC-MS / MS (Liquid Chromatography coupled with Tandem Mass Spectrometry) with a limit of quantification of around ten ppb in all types of products, formulations or raw materials.

Do not hesitate to contact us for further information.
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