Phthalates are substances added to plastics to improve their characteristics ( flexibility, transparency, elasticity, etc. ). Depending on the use of the latter as food or cosmetic packaging, toys, various objects ... a risk of migration is to be considered.
Certain phthalates such as DBP *, DIBP * or even BBP * have been classified as carcinogenic, mutagenic and reprotoxic substances by ECHA (European Chemicals Agency), their respective contents in materials must therefore be monitored.
Thanks to the analytical qualities of the UPLC-MS/MS (High Performance Liquid Chromatography coupled with Tandem Mass Spectrometry), it is possible to detect them up to trace levels, of the order of ten ug/L.
* DBP = Dibutyle Phthalate CAS [84-74-2]
* DIBP = Diisobutyl phthalate [84-69-5]
* BBP = Butyl benzyl phthalate CAS [85-68-7]
Likely to migrate from the polymer to the matrices in contact, the use of phthalates is now very closely monitored.
Different directives and regulations have been established depending on the sector of use of the material:
List (not exhaustive) of the compounds that can be targeted in UPLC / MS / MS analyzes:
Di-n-butylphthalate (DBP) - CAS 84-74-2
Di-isobutylphthalate (DIBP) - CAS 84-69-5
Bis (2-ethylhexyl) phthalate; di- (2-ethylhexyl) phthalate; DEHP (or “DOP“) - CAS 117-81-7
Benzylbutylphthalate (BBP) - CAS 85-68-7
Bis (2-Methoxyethyl) phthalate - CAS 117-82-8
Dimethyl phthalate (DMP) - CAS 131-11-3
Diethyl phthalate (DEP) - CAS 84-66-2
Di-n-propyl phthalate (DPP) - CAS 131-16-8
Di-n-pentyl phthalate (DNPP) - CAS 131-18-0
N-Pentyl-isopentylphthalate - CAS 776297-69-9
Di-n-hexyl phthalate (DNHP) - CAS 84-75-3
1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich - CAS 71888-89-6
1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters - CAS 68515-42-4
Dicyclohexyl phthalate (DCHP, DCP) - CAS 84-61-7
Di-n-octyl phthalate (DNOP) - CAS 117-84-0
Di-iso-pentyl phthalate (DIPP) - CAS 605-50-5
Di-iso-octyl phthalate (DIOP) - CAS 27554-26-3
Di-2-propyl heptyl phthalate (DPHP) - CAS 53306-54-0
Di-iso-nonyl phthalate (DINP) - CAS 28553-12-0
Di-n-nonyl phthalate (DNP), - CAS 84-76-4
Di-iso-decyl phthalate (DIDP) - CAS 26761-40-0